Canopus

Canopus (or Alpha Carinae) was the primary of the inhabited Canopus system. This system was located in the Alpha Quadrant. The location of Alpha Carinae in the Milky Way Galaxy was depicted on a Federation star chart in 2293. (, production art;, display graphic)

In 2267, on stardate 3046, USS Enterprise (NCC-1701) helmsman Hikaru Sulu used Canopus as a reference point to plot the location of the Enterprise after it was flung five hundred parsecs by the Metrons. 

In 2367, the star appeared on a chart in Captain Benjamin Maxwell's ready room on the USS Phoenix. (, display graphic)

In an alternate 2366, Alpha Carinae was marked on a tactical situation monitor showing the fleet deployments in the Federation-Klingon War. (, display graphic)