John F. Kennedy

John Fitzgerald Kennedy (1917-1963), also known as JFK, was a 20th century Human who served as the 35th President of the United States from 1961 until his assassination in 1963. 

In 1961, Kennedy gave a famous speech declaring his intentions of making the United States of America the first nation on Earth to go to the moon. An image depicting Kennedy's speech was scanned by the Talosians as they reviewed the library computer files on board USS Enterprise (NCC-1701) in 2254. ( remastered) A quote from this speech appeared on the USS Valiant (NCC-74210)'s dedication plaque: "We set sail on this new sea because there is new knowledge to be gained and new rights to be won."

Images of John F. Kennedy with his wife, Jacqueline Kennedy, was seen by Archer and Daniels when the timeline was reset in 1944/2154. 

In 2374, Vic Fontaine likened Shakaar Edon to JFK following Odo's description of Shakaar as "a leader, a hero, a man with great charisma."

The USS John F. Kennedy was named after him, as was the shuttlecraft JF Kennedy. 

Background
In the script of the Star Trek: Deep Space Nine episode, the writers likened the Bajoran response to the arrival of Li Nalas to Deep Space 9 to that of a hypothetical re-appearance of JFK thirty years after his assassination. The script states that "it's as if JFK had survived Dallas and suddenly appeared on a public street 30 years later".

Peter Lawford, one of the real-life Vegas entertainers mentioned in the Bashir 62 holoprogram, was Kennedy's brother-in-law in 1962, when the program is meant to take place.

The teaser trailer uses a portion of Kennedy's 1961 speech ("The eyes of the world now look into space.")