Calculus

Calculus is a method of mathematical calculation that has been adapted in several different forms, including fractal and waveform. On Earth, it was independently discovered by Sir Isaac Newton and Gottfried Leibniz. It has also been discovered and studied by such species as the Qomar and Vulcans, however, members of such advanced species as the Aldeans were not aware of the concept of calculus. 

T'Pol had a background in higher mathematics, including calculus. 

Harry Bernard hated calculus, despite the fact that his father told him everyone needed a basic understanding of it. 

Joshua Albert was never good at mathematics. His mother and father thought he would never understand calculus. This changed when Joshua found out it was one of the entry requirements of Starfleet Academy. He took on extra classes, got a personal tutor and passed the entry exams. 

Jake Sisko had a calculus test in 2370. 

Tincoo thought The Doctor's singing might be a form of waveform calculus.