Senility

Senility was a mental deterioration that affected the elderly. Among the more notable victims was Ambassador Sarek just before he died in 2368. 

In 2369, Els Renora stated to Commander Benjamin Sisko and Ilon Tandro during the trial of the Dax symbiont on Deep Space 9 that she wanted the proceedings to move swiftly and expected to be there until "supper, not senility."

''In the anti-time future, Jean-Luc Picard became inflicted with senility within the 2390s. This impacted his ability to warn others about the anti-time anomaly.''